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Pick a cancer immunotherapy agent, and present a summary of this immunotherapy
This should be a 1 page single spaced write up. Please pick a cancer immunotherapy agent, and present a summary of this immunotherapy that addresses the following questions: What is the name of this therapeutic agent, and which types of cancers or tumors is it often used to treat? What is the mechanism of action of this therapy? Please provide details about the cell types and signaling pathways that are targeted. What is the route of administration for this drug, and how often does it need to be administered? Are there any known side effects of using this therapy? Are patients left more susceptible to certain types of autoimmune disorders or infections? What is the prognosis for patients that are successfully treated with this therapy? You can pick an immunotherapy that is either already approved for use in humans, or one that is in clinical trials. You may choose a specific immunotherapy used to treat cancer that interests you after doing some of your own research, or select from this list of examples: Nivolumab or pembrolizumab (anti-PD1) Ipilimumab (anti-CTLA4) Rituximab (anti-CD20) Zevalin/Ibritumomab tiuxetan (anti-CD20 conjugated to yttrium-90) Anti-CD19 CAR T cells (many different types; Yescarta and Kymriah are 2 examples) Anti-CD19 CAR NK cells (several types; TAK-007 is a specific product in clinical trials) Provenge/Sipuleucel-T (dendritic cell vaccine) Herceptin/trastuzumab (anti-HER2) T-DM1/Trastuzumab emtansine (anti-HER2 conjugated to mertansine) Imiquimod (TLR7 agonist) Dynavax/CpG1018 (TLR9 agonist) Hu5F9-G4 (anti-CD47) Bemcentinib (TAM receptor inhibitor) Note that some of these drugs can be used to treat several different types of cancer; in this case, please pick 1 cancer type to discuss in your response. You should be able to present a summary of your chosen immunotherapy within a 1 page essay (NOT formatted as bullet points). Responses must be written in your own words. As with previous discussion prompts for this course, please include citations for the sources that you used to learn about this therapy at the end of your response (you may use any citation format that you prefer). Again, please keep in mind that there are 3 categories of scientific literature sources: (1) primary research articles, which are written by scientists and report their original experimental findings, (2) secondary research articles, which are review articles written by scientists that typically present a summary of a given topic without original experimental results, and (3) tertiary articles, which include pieces published in the popular media. Tertiary news sources represent venues of scientific communication that are more susceptible to influence by external social and cultural factors that may affect an article's objectivity, which can impact the quality and reliability of information that is presented. From a scientific standpoint, it is best to read about your topic of interest using primary and secondary research articles published by established journals, as these articles have been subjected to a scientific quality control process called peer review. You are strongly encouraged to find and read scientific literature on your selected immunotherapy that has been published in a reputable scientific journal using search engines such as PubMed (https://pubmed.ncbi.nlm.nih.gov (Links to an external site.) (Links to an external site.) (Links to an external site.)). If you have issues with additional journal access through your university and must include tertiary sources of information for this assignment, please include a short sentence with your citation that communicates why you trust that source of scientific information.

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